rs1061622

Warning: A non-numeric value encountered in /customers/e/2/1/mthfr-genetics.co.uk/httpd.www/library/wp-content/plugins/goo-pie-chart/goo-pie-chart.php on line 167 Warning: A non-numeric value encountered in /customers/e/2/1/mthfr-genetics.co.uk/httpd.www/library/wp-content/plugins/goo-pie-chart/goo-pie-chart.php on line 220

 

Chromosome 1
Position 12192898
Gene TNFRSF1B

TT (AA)

64.7.364.7%

GT (CA)

31.631.6%

GG (CC)

3.73.7%

Breakdown:

The G (C) allele is associated with:

  • GG (CC)= higher levels of tumor necrosis factor (TNF).
  • Increased risk in Inflammatory Bowel Disease.
  • GT (CA) is intermediate.

Research articles:

[PMID 19343543] Association analysis of TNFRSF1B polymorphisms with type 2 diabetes and its related traits in North India.

[PMID 19421420] Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population

[PMID 19684152] Cigarette smoking, STAT4 and TNFRSF1B polymorphisms, and systemic lupus erythematosus in a Japanese population

[PMID 21995493] TNFRSF1B +676 T>G polymorphism predicts survival of non-Small cell lung cancer patients treated with chemoradiotherapy

[PMID 15113403] Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis.

[PMID 16109524] Preparation and analysis of cSNP chip on hepatocellular carcinoma-related genes.

[PMID 16380915] Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.

[PMID 17705862] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 18248655] Genetic polymorphisms of tumour necrosis factor receptor superfamily 1A and 1B affect responses to infliximab in Japanese patients with Crohn’s disease.

[PMID 18385279] The tumour necrosis factor receptor superfamily member 1b 676T>G polymorphism in relation to response to infliximab and adalimumab treatment and disease severity in rheumatoid arthritis.

[PMID 18466472] Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.

[PMID 18466513] Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15.

[PMID 18603647] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II–endometriosis.

[PMID 19401444] Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism.

[PMID 20007930] A functional haplotype in the 3’untranslated region of TNFRSF1B is associated with tuberculosis in two African populations.

[PMID 20018049] Evaluation of an optimal receiver operating characteristic procedure.

[PMID 20646319] TNFRSF1B A1466G genotype is predictive of clinical efficacy after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.

[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 22860894] Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn’s disease

[PMID 23799986] Maternal tumor necrosis factor receptor 2 gene variants associated with pre-eclampsia in Tunisian women

[PMID 22921902] The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure.

[PMID 23238918] Genome-wide pathway analysis of a genome-wide association study on multiple sclerosis.

[PMID 25010932] Association of TNF-α, TNFRSF1A and TNFRSF1B Gene Polymorphisms with the Risk of Sporadic Breast Cancer in Northeast Chinese Han Women

[PMID 25850964] Genetic variants within the TNFRSF1B gene and susceptibility to rheumatoid arthritis and response to anti-TNF drugs: a multicenter study

[PMID 26071216] The tumor necrosis factor receptor superfamily member 1B polymorphisms predict response to anti-TNF therapy in patients with autoimmune disease: A meta-analysis. 

EXPRESSION CONTROL

Decrease activity ↓
Tetradecanoylphorbol Acetate Decreases expression  , Decreases reaction  (R) , (R)
Ionomycin Decreases expression  , Decreases reaction  (R) , (R)
Arsenic trioxide Decreases expression  (R)
Pyrrolidine dithiocarbamic acid Decreases expression  , Decreases reaction  (R) , (R)
Bathocuproine sulfonate Decreases expression  , Decreases reaction  (R) , (R)
Cadmium Chloride Decreases expression  (R)
N-Methyl-3,4-methylenedioxyamphetamine Decreases expression  (R)
Benzo(a)pyrene Decreases expression  (R)
Lead acetate Decreases expression  (R)
Estrogen Decreases expression  (R)
Neoechinulin Decreases expression  (R)
Asbestos Decreases expression  (R)
Nickel Decreases expression  (R)
Ferrite Decreases expression  (R)
Gefitinib Decreases expression  (R)
Indole-3-carbinol Decreases expression  (R)
Lenalidomide Decreases expression  (R)
Sodium arsenite Decreases expression  (R)
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide Decreases expression  (R)
Tetraarsenic tetrasulfide Decreases expression  (R)
Acetylcysteine Decreases expression  (R)
Air Pollutants, Occupational Decreases expression  (R)
Aluminum Decreases expression  (R)
Antimony Sodium Gluconate Decreases expression  (R)
Antirheumatic Agents Decreases expression  (R)
Arsenicals Decreases methylation  (R)
Cuprizone Decreases expression  (R)
Dextrans Decreases expression  (R)
Diethylnitrosamine Decreases expression  (R)
Hydrogen Peroxide Decreases response to substance  (R)
Imatinib Mesylate Decreases expression  (R)
Methyl Methanesulfonate Decreases expression  (R)
Oxidopamine Decreases response to substance  (R)
Progesterone Decreases expression  (R)
Simvastatin Decreases expression  (R)
TMC 120A Decreases expression  (R)
Thalidomide Decreases expression  (R)
Alfacalcidol Decreases expression  (R)
Arsenite Decreases expression  (R)
Chromium oxide Decreases expression  (R)
Chromous chloride Decreases expression  (R)
Cupric chloride Decreases expression  (R)

 

 

Increase activity
Lipopolysaccharides Increases expression  (R)
Pirinixic acid Increases activity  , Increases expression  (R) , (R)
(+)-JQ1 compound Increases expression  (R)

 

Bleomycin Increases response to substance  (R)
Ketoconazole Increases expression  (R)
Octreotide Increases expression  (R)
SB 203580  Increases expression  (R)
Vehicle Emissions Increases expression  (R)
Procyanidin B3  Increases expression  (R)
Terameprocol  Increases expression  (R)
Carbon Monoxide Increases expression  (R)
Magnetite Nanoparticles Increases expression  (R)
Melatonin Increases response to substance  (R)
Mycophenolic Acid Increases expression  (R)
Nitrogen Dioxide Increases expression  (R)
C646 compound Increases expression  (R)
Sanguinarine Increases expression  (R)
Oleanolic Acid Increases expression  (R)
Azacitidine Increases expression  (R)
PLX4032 Increases expression  (R)
Pentachlorophenol Increases expression  (R)
Polycyclic Hydrocarbons, Aromatic Increases expression  (R)
Propylthiouracil Increases expression  (R)
Quercetin Increases expression  (R)
Zoledronic acid Increases expression  (R)
3,3-dimethylallyl pyrophosphate Increases expression  (R)
Succimer Increases expression  (R)
Titanium dioxide Increases expression  (R)
WR 1065 Increases activity  (R)
Zymosan Increases expression  (R)
Abrine Increases expression  (R)
Aloe emodin Increases expression  (R)
Bisphenol A Increases expression  (R)
Brevianamide A Increases expression  (R)
Butylphen Increases expression  (R)
Fusarenon-X Increases expression  (R)
Hopane Increases expression  (R)
N-butoxyethanol Increases expression  (R)
Nickel sulfate Increases expression  (R)
Pantogab Increases expression  (R)
2-(1’H-indolo-3′-carbonyl)thiazole-4-carboxylic acid methyl ester Increases expression  (R)
Vinclozolin Increases expression  (R)
Dust Increases expression  (R)
Environmental Pollutants Increases expression  (R)
Ethinyl Estradiol Increases expression  (R)
Dextran Sulfate Increases expression  (R)
Resveratrol Increases response to substance  (R)
Lead Increases expression  (R)

 

Can work both ways
Ozone  Decreases reaction  (R)
Streptozocin  Decreases reaction  (R)
Curcumin  Decreases reaction  (R)
Glucosamine  Decreases reaction  (R)
Terameprocol  Decreases reaction  (R)
Procyanidin B3  Decreases reaction  (R)