| Chromosome | 2 |
| Position | 138014190 |
| Gene | HNMT |
AA CT CC58.1 58.1% 34.8 34.8% 7.1 7.1%
Breakdown:
Each A allele means an increased risk of food dye sensitivity and ADHD behavious in children.
This SNP is part of the HNMT gene known as T939C (or 939A>G) that regulates histamine.
According to [PMID 20551163] the lack of a G allele (GG and AG genotypes) for this gene indicates an increase in ADHD behavior for children age 3 and 8/9 when they have been exposed to certain food additives: sunset yellow, carmoisine, tartrazine, ponceau 4R, quinoline yellow, allura red AC and sodium benzoate
Research studiesEXPRESSION CONTROL
SAMe (S-Adenosyl Methionine), which is the end product of the Methylation Cycle and also the main Methyl Donor, is a substrate for the HNMT gene. This means that this gene needs the Mthylation Cycle to be optimised in order to be able to work to its’ full capacity.
Increase activity ↑Benzopyrene
Vorinostat
Histamine
Phenylmercuric Acetate
Valproic Acid
Mercuric bromide
Panobinostat
Trichostatin A
Mustard Gas
Plant Extracts
Arsenite
Vitamin E
Selenium
Estrogen
Quercetin
Silicon Dioxide
Zinc
Depending on real-time status ot the HNMT gene expression, the below compounds can either slow down or increase HNMT gene function:
DUSCUSSION & TIPS
HNMT inactivates intracellular histamine by N-methylation using SAMe as its’ substrate. This gene plays an important role in degrading histamine and in regulating the airway response to histamine.
Once Histamine is degraded to N-methylhistamine by HNMT it then has to be handled by MAO B and ADH gene.
Please open the chart below to understand the full process.