| Chromosome | 7 |
| Position | 150856517 |
| Gene | AOC1 / DAO |
CC CT TT50 50.5% 35.7 36% 13.4 13.5%
Science:
T allele:
- Reduced levels of Diamine Oxidase (DAO) protein (Ref).
- Indicates poor histamine breakdown due to decreased DAO activity, compared to the CC genotype.[PMID 21488903]
- Higher sensitivity to aspirin, ibuprofen (Ref).
- Increased risk of migraines (Ref).
C allele:
- Normal levels of Diamine Oxidase (DAO) protein
EXPRESSION CONTROL
Increase activity ↑| Acetaminophen | Increases expression | (Ref) |
| Amphotericin B, deoxycholate drug combination | Increases expression | (Ref) |
| Atrazine | Increases expression | (Ref) |
| AZM551248 | Increases expression | (Ref) |
| Choline | Increases expression | (Ref) |
| Colforsin | Increases activity | (Ref) |
| Cupric chloride | Increases activity | (Ref) |
| Diethylnitrosamine | Increases expression | (Ref) |
| Diethylstilbestrol | Increases expression | (Ref) |
| Estrogen | Increases expression | |
| Gamma-Aminobutyric Acid | Increases abundance | (Ref) |
| Genistein | Increases expression | (Ref) |
| Halofuginone | Increases expression | (Ref) |
| Histamine | Increases metabolic processing | (Ref) |
| Hydralazine | Increases expression | (Ref) |
| Methionine | Increases expression | (Ref) |
| Methylfolate | Increases expression | (Ref) |
| Nickel | Increases expression | (Ref) |
| Nickel sulfate | Increases expression | (Ref) |
| Oxazolone | Increases expression | (Ref) |
| Oxygen | Increases expression | (Ref) |
| Perfluorooctanoic acid | Increases expression | (Ref) |
| Pirinixic acid | Increases expression | (Ref) |
| Tele-methylhistamine | Increases metabolic processing | (Ref) |
| Valproic Acid | Increases expression | (Ref) |
| Benzo(a)pyrene | Decreases expression | |
| Chloroprene | Decreases expression | (Ref) |
| Clofibrate | Decreases expression | (Ref) |
| Cyclosporine | Decreases expression | (Ref) |
| Diaminobutene | Decreases activity | (Ref) |
| Sodium arsenate | Decreases expression | (Ref) |
| Sodium bichromate | Decreases expression | (Ref) |
| Spermidine | Decreases expression | (Ref) |
| Titanium dioxide | Decreases expression | (Ref) |
| Vancomycin | Decreases expression | (Ref) |
| Theophylline | Decreases expression | (Ref) |
| Cadmium Chloride | Decreases expression | (Ref) |
| Sodium arsenite | Decreases expression | (Ref) |
| Pimagedine | Decreases activity | (Ref) |
Can work both ways ↑↓