Gene description
This gene plays a major role in ketone body metabolism.
Gene function
Disease association
Advanced information
The following transcription factors affect gene expression (R):
- GR-alpha
- GR-beta
- GR
- PPAR-alpha
- SREBP-1a
- SREBP-1b
- SREBP-1c
Gene Pathways:
- Butanoate metabolism
- Pyruvate metabolism
- Propanoate metabolism
- Terpenoid backbone biosynthesis
- Synthesis and degradation of ketone bodies
- Valine, leucine and isoleucine degradation
- Metabolism
- Metabolic pathways
- Glyoxylate and dicarboxylate metabolism
- Fatty acid metabolism
- Lysine degradation
- Tryptophan metabolism
Enzyme Regulation:
Activated by potassium ions, but not sodium ions.
Molecular Function:
- Acetyl-Coa C-Acetyltransferase Activity
- Carbon-Carbon Lyase Activity
- Coenzyme Binding
- Ligase Activity, Forming Carbon-Carbon Bonds
- Metal Ion Binding
Biological Processes:
- Acetyl-Coa Biosynthetic Process
- Acetyl-Coa Catabolic Process
- Adipose Tissue Development
- Brain Development
- Branched-Chain Amino Acid Catabolic Process
- Coenzyme A Biosynthetic Process
- Coenzyme A Metabolic Process
- Fatty Acid Beta-Oxidation
- Isoleucine Catabolic Process
- Ketone Body Biosynthetic Process
- Ketone Body Catabolic Process
- Ketone Body Metabolic Process
- Liver Development
- Metanephric Proximal Convoluted Tubule Development
- Propionyl-Coa Biosynthetic Process
- Protein Homooligomerization
- Response To Hormone
- Response To Organic Cyclic Compound
- Response To Starvation
Drug Bank:
