rs662

Chromosome 7
Position 94937445
Gene PON1

CT

42.942.9%

CC

32.932.9%

TT

24.324.3%

Breakdown:

The T   allele is associated with:

  • TT = 2.3X higher risk of coronary heart disease
  • TT = Increased risk of vascular dementia  (Ref)
  • TT = Increased risk of kidney disease
  • TT = Ischemic heart disease  (Ref).
  • TT = Kidney disease  (Ref).
  • TT or TC associated with Male infertility (Ref).
  • T  is usually associated with decreased blood levels of PON1 (RefRef) and lower PON1 activity (Ref), which explains why CT  or CC  have a 43% lower risk of breast cancer in one study (Ref).
  • TT  breaks down oxidized LDL better (RefRef), whereas CC  detoxes most organophosphate (including chlorpyrifos oxon , diazoxon, sarin, and soman) pesticides better (Ref) (RefRef).
  • T is 2X more efficient at breaking down oxidized lipids (such as oxLDL) (Ref )
  • The T encodes a glutamine (“Q”), C encodes an arginine (“R”) (Ref).

The C allele is associated with:

  • Prenatally pesticide-exposed children carrying the C allele had higher abdominal circumference, body fat content, BMI, blood pressure, leptin and IGF-1 at school age than unexposed children. The effects were related to the prenatal exposure level.  For children with TT , none of the variables was affected by prenatal pesticide exposure.  Only exposed children with the C allele developed adverse heart disease risk profiles thought to be associated with the C allele. (Ref)
  • CC = Increased risk of Alzheimers Disease  (Ref)
  • CC = Increased anxiety  (Ref).
  • C; Heart disease.  A weak association between the C allele and increased heart disease risk has been confirmed in most case-control studies, and is supported by meta-analyses (RefRefRefRef). In combination with low serum HDL and the CC  markedly increased the risk of heart disease (Ref).
  • Increased diabetes risk (CC) (Ref). Type 2 diabetics with either one or two C  alleles had a 9 fold higher risk of heart disease compared with TT  (Ref).
  • The C  allele results in eight times more efficient enzyme activity than T concerning some organophosphates) (Ref).
  • C lowered arylesterase activity in people with Autism, but not in healthy people (Ref).

Research articles:


EXPRESSION CONTROL


Compounds that Decrease PON1 activity ↓


Increase activity

Can work both ways