rs662 – Lifestyle Genomics Research Centre

Chromosome

Position

94937445

Gene

CT	42.9	42.9%
CC	32.9	32.9%
TT	24.3	24.3%

Breakdown:

The T allele is associated with:

TT = 2.3X higher risk of coronary heart disease
TT = Increased risk of vascular dementia (Ref)
TT = Increased risk of kidney disease
TT = Ischemic heart disease (Ref).
TT = Kidney disease (Ref).
TT or TC associated with Male infertility (Ref).
T is usually associated with decreased blood levels of PON1 (Ref, Ref) and lower PON1 activity (Ref), which explains why CT or CC have a 43% lower risk of breast cancer in one study (Ref).
TT breaks down oxidized LDL better (Ref, Ref), whereas CC detoxes most organophosphate (including chlorpyrifos oxon , diazoxon, sarin, and soman) pesticides better (Ref) (Ref, Ref).
T is 2X more efficient at breaking down oxidized lipids (such as oxLDL) (Ref )
The T encodes a glutamine (“Q”), C encodes an arginine (“R”) (Ref).

The C allele is associated with:

Prenatally pesticide-exposed children carrying the C allele had higher abdominal circumference, body fat content, BMI, blood pressure, leptin and IGF-1 at school age than unexposed children. The effects were related to the prenatal exposure level. For children with TT , none of the variables was affected by prenatal pesticide exposure. Only exposed children with the C allele developed adverse heart disease risk profiles thought to be associated with the C allele. (Ref)
CC = Increased risk of Alzheimers Disease (Ref)
CC = Increased anxiety (Ref).
C; Heart disease. A weak association between the C allele and increased heart disease risk has been confirmed in most case-control studies, and is supported by meta-analyses (Ref, Ref, Ref, Ref). In combination with low serum HDL and the CC markedly increased the risk of heart disease (Ref).
Increased diabetes risk (CC) (Ref). Type 2 diabetics with either one or two C alleles had a 9 fold higher risk of heart disease compared with TT (Ref).
The C allele results in eight times more efficient enzyme activity than T concerning some organophosphates) (Ref).
C lowered arylesterase activity in people with Autism, but not in healthy people (Ref).

Research articles:

EXPRESSION CONTROL

Compounds that Decrease PON1 activity ↓

Carbon Tetrachloride

Decreases abundance , Decreases reaction

(R) , (R)

Soman	Decreases activity , Decreases reaction	(R) , (R)
Copper Sulfate	Decreases activity , Decreases reaction	(R) , (R)
Dichlorvos	Decreases activity , Decreases reaction	(R) , (R)
Organophosphorus Compounds	Decreases expression	(R)

Sarin	Decreases activity , Decreases reaction	(R) , (R)
Cyclohexyl methylphosphonofluoridate	Decreases response to substance	(R)
Polyethylene Glycols	Decreases activity , Decreases reaction	(R) , (R)

Iron	Decreases expression , Decreases reaction	(R) , (R)
Trans-10,cis-12-conjugated linoleic acid	Decreases activity , Decreases reaction	(R) , (R)

Palmitoleic acid

Decreases activity , Decreases reaction

(R) , (R)

Hydroxymercuribenzoates	Decreases activity , Decreases reaction	(R)
1,2-dioleoyl-sn-glycero-3-phosphoglycerol	Decreases activity , Decreases reaction	(R) , (R)
Pesticides	Decreases activity	(R)

Anthra(1,9-cd)pyrazol-6(2H)-one	Decreases expression , Decreases reaction	(R) , (R)
Tetrachlorodibenzodioxin	Decreases expression	(R)
Rutin	Decreases expression , Decreases reaction	(R) , (R)
Plant Extracts	Decreases activity , Decreases reaction	(R) , (R)
Vitamin E	Decreases activity , Decreases reaction	(R) , (R)
Chenodeoxycholic Acid	Decreases expression , Decreases reaction	(R) , (R)

Methyl Parathion

Decreases activity , Decreases expression

(R) , (R)

Selenium	Decreases activity , Decreases reaction	(R) , (R)
1,2-oleoylphosphatidylcholine	Decreases activity , Decreases reaction	(R) , (R)

Perfluorooctanoic acid

Decreases expression

(R)

Methylmercury Compounds

Decreases activity

(R) ( R)

Butylated Hydroxytoluene	Decreases expression , Decreases reaction	(R)
Tabun	Decreases response to substance	(R)

Tempol	Decreases activity , Decreases reaction	(R) , (R)
Glutathione	Decreases abundance , Decreases reaction	(R) , (R)

Cholesterol	Decreases chemical synthesis	(R)
Erucic acid	Decreases activity , Decreases reaction	(R) , (R)

VX	Decreases response to substance	(R)
Environmental Pollutants	Decreases activity	(R)

4-hydroxymercuribenzoate

Decreases activity

(R)

Taurocholic Acid

Decreases expression

(R)

Vorinostat	Decreases expression	(R)
1,4-bis(2-(3,5-dichloropyridyloxy))benzene	Decreases expression	(R)
Ampicillin	Decreases activity	(R)
Cholic Acid	Decreases expression	(R)
Ciprofloxacin	Decreases activity	(R)
Clofibrate	Decreases expression	(R)
Clofibric Acid	Decreases expression	(R)
Estrogen	Decreases expression	(R)

Mercury

Decreases activity

(R)

Propylthiouracil	Decreases activity	(R)
Silicon Dioxide	Decreases expression	(R)

Clindamycin phosphate

Decreases activity

(R)

Hydrazine	Decreases expression	(R)
Naphthalene	Decreases expression	(R)
Panobinostat	Decreases expression	(R)
Rosiglitazone	Decreases expression	(R)
Soot	Decreases expression	(R R)
Sodium Selenite	Decreases expression	(R)
Reactive Oxygen Species	Decreases activity	(R)
Phenytoin	Decreases expression	(R)
Fumonisin B1	Decreases expression	(R)
Furan	Decreases expression	(R)
2,5,2′,5′-tetrachlorobiphenyl	Decreases expression	(R)
Titanium dioxide	Decreases expression	(R)
Phenylmercuric Acetate	Decreases expression	(R)
Ozone	Decreases expression	(R)
Nandrolone decanoate	Decreases activity	(R)
2,3-pentanedione	Decreases expression	(R)
Ochratoxin A	Decreases expression	(R)
Nicotine	Decreases activity	(R)
Trichostatin A	Decreases expression	(R)
Methotrexate	Decreases expression	(R)
Endosulfan	Decreases expression	(R)
Edetic Acid	Decreases activity	(R)
Dietary Fats, Unsaturated	Decreases expression	(R)
Cyclosporine	Decreases expression	(R)
1,2-dithiol-3-thione	Decreases expression	(R)
Sodium arsenite	Decreases expression	(R)
Bisphenol A	Decreases expression	(R)
Ciprofibrate	Decreases expression	(R)
BIRB 796	Decreases expression	(R)
Bexarotene	Decreases expression	(R)
Allyl sulfide	Decreases expression	(R)
Tamoxifen	Decreases expression	(R)

Increase activity ↑

Paraoxon

Increases metabolic processing , Increases reaction

(R) , (R)

3,4,5,3′,4′-pentachlorobiphenyl	Increases expression	(R)
Cholesterol, HDL	Increases activity	(R)
Insecticides	Increases mutagenesis	(R)
Calcium	Increases stability	(R)
Oleic Acid	Increases stability	(R)
Phenyl acetate	Increases hydrolysis	(R)

Chlorpyrifos	Increases activity	(R)
Cadmium	Increases metabolic processing , Increases reaction	(R) , (R)

Aspirin	Increases activity	(R)
Diethylnitrosamine	Increases expression	(R)
CLA	Increases activity	(R)

Calcium Chloride

Increases hydrolysis , Increases reaction

(R) , (R)

Atorvastatin Calcium

Increases activity

(R), ( R)

Dieldrin

Increases expression

(R)

Benzo(a)pyrene

Increases expression

(R)

Acrolein

Increases metabolic processing

(R)

4-nitrophenyl acetate	Increases hydrolysis	(R)
Oxygen	Increases reaction	(R)
Nitroaspirin	Increases activity	(R)
Parathion	Increases metabolic processing	(R)

Dexamethasone	Increases expression	(R)
Plant Preparations	Increases activity	(R)

Salicylates

Increases activity

(R)

Sodium bichromate	Increases expression	(R)
2,4,5,2′,4′,5′-hexachlorobiphenyl	Increases expression	(R)
2-oxo-clopidogrel	Increases hydrolysis	(R)
4-nitrophenol	Increases chemical synthesis	(R)
Acetylcysteine	Increases activity	(R)
Cisplatin	Increases expression	(R)
Coumarins	Increases hydrolysis	(R)
Cyclophosphamide	Increases activity	(R)
Fatty Acids, Monounsaturated	Increases activity	(R)
Fenofibrate	Increases expression	(R)
Lactones	Increases hydrolysis	(R)
Metformin	Increases response to substance	(R)
Methimazole	Increases activity	(R)
N-nitrosomorpholine	Increases expression	(R)
Obidoxime Chloride	Increases hydrolysis	(R)
Olive Oil	Increases activity	(R)
Omacor	Increases expression	(R)
Phenylacetates	Increases metabolic processing	(R)
Plant Oils	Increases activity	(R)
Polychlorinated Biphenyls	Increases expression	(R)
Polycyclic Hydrocarbons, Aromatic	Increases response to substance	(R)
Progesterone	Increases expression	(R)
Rifampin	Increases expression	(R)
S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate	Increases hydrolysis	(R)
Thiobarbituric Acid Reactive Substances	Increases abundance	(R)
Benzo(k)fluoranthene	Increases expression	(R)
Bifenthrin	Increases expression	(R)
Chromic chloride	Increases expression	(R)
Decabromobiphenyl ether	Increases expression	(R)
Decan-4-olide	Increases hydrolysis	(R)
Entinostat	Increases expression	(R)
Flavone	Increases expression	(R)
Lipopolysaccharide, E coli O55-B5	Increases expression	(R)
Methylmercuric chloride	Increases expression	(R)
Naringenin	Increases expression	(R)
Orlistat	Increases activity	(R) (R)
Propionaldehyde	Increases expression	(R)
1,2-dilauroylphosphatidylcholine	Increases activity	(R)

Can work both ways ↑↓

Copper	Increases metabolic processing	(R)
Phenylacetic acid	Increases hydrolysis	(R)
Simvastatin	Increases expression	(R)
Resveratrol	Increases expression	(R)

Oximes	Increases hydrolysis , Increases reaction	(R) , (R)
Hydrogen Peroxide	Increases hydrolysis	(R)

Quercetin

Increases expression

(R)

Ethyl 4-nitrophenyl methylphosphonate	Increases hydrolysis , Increases reaction	(R) , (R)
Selenic Acid	Increases expression	(R)
4-nitrophenyl 2-propylmethylphosphonate	Increases hydrolysis , Increases reaction	(R) , (R)
Linoleic Acid	Increases hydrolysis	(R)
Cumene hydroperoxide	Increases oxidation	(R)
2-hydroxyquinoline	Increases hydrolysis	(R)

Isoflurophate	Increases hydrolysis	(R)
Methylcholanthrene	Increases expression	(R)

Pitavastatin

Increases expression

(R)

Substances of Biological Interest

Ferrous sulfate	Increases hydrolysis	(R)
Fluvastatin	Increases hydrolysis	(R)
Pyruvaldehyde	Increases hydrolysis	(R)
4-hydroxy-2-nonenal	Increases hydrolysis	(R)
Arachidonic Acid	Increases hydrolysis	(R)
Nickel	Increases metabolic processing	(R)
Mevalonic Acid	Increases expression	(R)
Lead	Increases metabolic processing	(R)
Hypochlorous Acid	Increases reaction	(R)
7-ketocholesterol	Increases expression	(R)
Pirinixic acid	Increases activity	(R)
Sulfhydryl Compounds	Increases reaction	(R)
Zinc	Increases metabolic processing	(R)

Farnesyl pyrophosphate	Increases expression	(R)
1,2-dipalmitoylphosphatidylglycerol	Increases reaction	(R)
Lysophosphatidylglycerol	Increases hydrolysis	(R)
Lysophosphatidylinositol	Increases hydrolysis	(R)
Homocysteine	Increases abundance	(R)

Manganese

Increases metabolic processing

(R)

Malondialdehyde

Increases abundance

(R)

Geranylgeranyl pyrophosphate

Increases expression

(R)

Plicamycin

Increases expression

(R)

Squalene	Increases expression	(R)
Methionine	Increases abundance	(R)