rs854571

[PMID 23356507] Association between paraoxonase gene and stroke in the Han Chinese population

[PMID 24448003] Methylmercury exposure, PON1 gene variants and serum paraoxonase activity in Eastern James Bay Cree adults

[PMID 22704918] Association of a protective paraoxonase 1 (PON1) polymorphism in Parkinson’s disease.

How to increase PON1:

• Vitamin E
• Mediterranean Diet (R),
• Extra Virgin Olive Oil (R),
• Fish oil/DHA (R, R2),
• Broccoli sprouts/Sulforaphane (R),
• Allyl isothiocyanate (found in mustard, radish, wasabi) (R)
• Curcumin (R),

Mitigate things that decrease PON1: 

• Omega-6s such as linolenic acid and arachidonic acid decrease PON1 (R).
• Low grade inflammation will decrease PON1, so you should fix general inflammation (R).
• PON1 in human blood is inactivated by oxidized LDL and preserved by antioxidants (R), so taking care of oxidative stress in general is a good idea.

Carbon Tetrachloride

Decreases abundance  , Decreases reaction

(R) , (R)

Soman	Decreases activity  , Decreases reaction	(R) , (R)
Copper Sulfate	Decreases activity  , Decreases reaction	(R) , (R)
Dichlorvos	Decreases activity  , Decreases reaction	(R) , (R)
Organophosphorus Compounds	Decreases expression	(R)

Sarin	Decreases activity  , Decreases reaction	(R) , (R)
Cyclohexyl methylphosphonofluoridate	Decreases response to substance	(R)
Polyethylene Glycols	Decreases activity  , Decreases reaction	(R) , (R)

Iron	Decreases expression  , Decreases reaction	(R) , (R)
Trans-10,cis-12-conjugated linoleic acid	Decreases activity  , Decreases reaction	(R) ,  (R)

Palmitoleic acid

Decreases activity  , Decreases reaction

(R) , (R)

Hydroxymercuribenzoates	Decreases activity  , Decreases reaction	(R)
1,2-dioleoyl-sn-glycero-3-phosphoglycerol	Decreases activity  , Decreases reaction	(R) , (R)
Pesticides	Decreases activity	(R)

Anthra(1,9-cd)pyrazol-6(2H)-one	Decreases expression  , Decreases reaction	(R) , (R)
Tetrachlorodibenzodioxin	Decreases expression	(R)
Rutin	Decreases expression  , Decreases reaction	(R) , (R)
Plant Extracts	Decreases activity  , Decreases reaction	(R) , (R)
Vitamin E	Decreases activity  , Decreases reaction	(R) , (R)
Chenodeoxycholic Acid	Decreases expression  , Decreases reaction	(R) , (R)

Methyl Parathion

Decreases activity  , Decreases expression

(R) , (R)

Selenium	Decreases activity  , Decreases reaction	(R) , (R)
1,2-oleoylphosphatidylcholine	Decreases activity  , Decreases reaction	(R) , (R)

Perfluorooctanoic acid

Decreases expression

(R)

Methylmercury Compounds

Decreases activity

(R) ( R)

Butylated Hydroxytoluene	Decreases expression  , Decreases reaction	(R)
Tabun	Decreases response to substance	(R)

Tempol	Decreases activity  , Decreases reaction	(R) , (R)
Glutathione	Decreases abundance  , Decreases reaction	(R) , (R)

Cholesterol	Decreases chemical synthesis	(R)
Erucic acid	Decreases activity  , Decreases reaction	(R) , (R)

VX	Decreases response to substance	(R)
Environmental Pollutants	Decreases activity	(R)

4-hydroxymercuribenzoate

Decreases activity

(R)

Taurocholic Acid

Decreases expression

(R)

Vorinostat	Decreases expression	(R)
1,4-bis(2-(3,5-dichloropyridyloxy))benzene	Decreases expression	(R)
Ampicillin	Decreases activity	(R)
Cholic Acid	Decreases expression	(R)
Ciprofloxacin	Decreases activity	(R)
Clofibrate	Decreases expression	(R)
Clofibric Acid	Decreases expression	(R)
Estrogen	Decreases expression	(R)

Mercury

Decreases activity

(R)

Propylthiouracil	Decreases activity	(R)
Silicon Dioxide	Decreases expression	(R)

Clindamycin phosphate

Decreases activity

(R)

Hydrazine	Decreases expression	(R)
Naphthalene	Decreases expression	(R)
Panobinostat	Decreases expression	(R)
Rosiglitazone	Decreases expression	(R)
Soot	Decreases expression	(R R)
Sodium Selenite	Decreases expression	(R)
Reactive Oxygen Species	Decreases activity	(R)
Phenytoin	Decreases expression	(R)
Fumonisin B1	Decreases expression	(R)
Furan	Decreases expression	(R)
2,5,2′,5′-tetrachlorobiphenyl	Decreases expression	(R)
Titanium dioxide	Decreases expression	(R)
Phenylmercuric Acetate	Decreases expression	(R)
Ozone	Decreases expression	(R)
Nandrolone decanoate	Decreases activity	(R)
2,3-pentanedione	Decreases expression	(R)
Ochratoxin A	Decreases expression	(R)
Nicotine	Decreases activity	(R)
Trichostatin A	Decreases expression	(R)
Methotrexate	Decreases expression	(R)
Endosulfan	Decreases expression	(R)
Edetic Acid	Decreases activity	(R)
Dietary Fats, Unsaturated	Decreases expression	(R)
Cyclosporine	Decreases expression	(R)
1,2-dithiol-3-thione	Decreases expression	(R)
Sodium arsenite	Decreases expression	(R)
Bisphenol A	Decreases expression	(R)
Ciprofibrate	Decreases expression	(R)
BIRB 796	Decreases expression	(R)
Bexarotene	Decreases expression	(R)
Allyl sulfide	Decreases expression	(R)
Tamoxifen	Decreases expression	(R)

 

Paraoxon

Increases metabolic processing  , Increases reaction

(R) , (R)

3,4,5,3′,4′-pentachlorobiphenyl	Increases expression	(R)
Cholesterol, HDL	Increases activity	(R)
Insecticides	Increases mutagenesis	(R)
Calcium	Increases stability	(R)
Oleic Acid	Increases stability	(R)
Phenyl acetate	Increases hydrolysis	(R)

Chlorpyrifos	Increases activity	(R)
Cadmium	Increases metabolic processing  , Increases reaction	(R) , (R)

Aspirin	Increases activity	(R)
Diethylnitrosamine	Increases expression	(R)
CLA	Increases activity	(R)

Calcium Chloride

Increases hydrolysis  , Increases reaction

(R) , (R)

Atorvastatin Calcium

Increases activity

(R), ( R)

Dieldrin

Increases expression

(R)

 

Benzo(a)pyrene

Increases expression

(R)

Acrolein

Increases metabolic processing

(R)

4-nitrophenyl acetate	Increases hydrolysis	(R)
Oxygen	Increases reaction	(R)
Nitroaspirin	Increases activity	(R)
Parathion	Increases metabolic processing	(R)

Dexamethasone	Increases expression	(R)
Plant Preparations	Increases activity	(R)

Salicylates

Increases activity

(R)

Sodium bichromate	Increases expression	(R)
2,4,5,2′,4′,5′-hexachlorobiphenyl	Increases expression	(R)
2-oxo-clopidogrel	Increases hydrolysis	(R)
4-nitrophenol	Increases chemical synthesis	(R)
Acetylcysteine	Increases activity	(R)
Cisplatin	Increases expression	(R)
Coumarins	Increases hydrolysis	(R)
Cyclophosphamide	Increases activity	(R)
Fatty Acids, Monounsaturated	Increases activity	(R)
Fenofibrate	Increases expression	(R)
Lactones	Increases hydrolysis	(R)
Metformin	Increases response to substance	(R)
Methimazole	Increases activity	(R)
N-nitrosomorpholine	Increases expression	(R)
Obidoxime Chloride	Increases hydrolysis	(R)
Olive Oil	Increases activity	(R)
Omacor	Increases expression	(R)
Phenylacetates	Increases metabolic processing	(R)
Plant Oils	Increases activity	(R)
Polychlorinated Biphenyls	Increases expression	(R)
Polycyclic Hydrocarbons, Aromatic	Increases response to substance	(R)
Progesterone	Increases expression	(R)
Rifampin	Increases expression	(R)
S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate	Increases hydrolysis	(R)
Thiobarbituric Acid Reactive Substances	Increases abundance	(R)
Benzo(k)fluoranthene	Increases expression	(R)
Bifenthrin	Increases expression	(R)
Chromic chloride	Increases expression	(R)
Decabromobiphenyl ether	Increases expression	(R)
Decan-4-olide	Increases hydrolysis	(R)
Entinostat	Increases expression	(R)
Flavone	Increases expression	(R)
Lipopolysaccharide, E coli O55-B5	Increases expression	(R)
Methylmercuric chloride	Increases expression	(R)
Naringenin	Increases expression	(R)
Orlistat	Increases activity	(R) (R)
Propionaldehyde	Increases expression	(R)
1,2-dilauroylphosphatidylcholine	Increases activity	(R)