Peroxisome proliferator activated receptor alpha
Gene description
The PPARA gene encodes peroxisome proliferator activated receptor alpha ( PPAR alpha ), an important enzyme for metabolizing fat and glucose (Ref).
Gene function
PPAR-alpha signals the liver to break down more fat. When you’re fasting and there aren’t enough carbs in your body to burn for energy, PPAR-alpha helps trigger ketogenesis, the process of burning fat for energy .
Variants in PPARA have been linked to:
- Heart function at high altitude
- Headache at high altitude
- Drug side effects
- Cholesterol levels
Disease association
Advanced Information
The following transcription factors affect gene expression:
- ER-alpha
- PPAR-gamma1
- PPAR-gamma2
- AP-1
- c-Jun
- PPAR-alpha
- C/EBPalpha
- HNF-4alpha1
- HNF-4alpha2
- STAT5B
- SIRT1
- PGC-1alpha
- RXR-alpha
Tissue specificity:
Skeletal muscle, liver, heart and kidney.
Gene Pathways:
- Adipocytokine signaling pathway
- Mus musculus biological processes
- PPAR signaling pathway
- Gene Expression
- Circadian Clock
- Metabolism
- Hepatitis C
Molecular Function:
- Dna Binding
- Drug Binding
- Lipid Binding
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Repressing Transcription Factor Binding
- Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
- Sequence-Specific Dna Binding
- Steroid Hormone Receptor Activity
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Factor Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Binding
- Ubiquitin Conjugating Enzyme Binding
- Zinc Ion Binding
Biological Processes:
- Behavioral Response To Nicotine
- Cellular Lipid Metabolic Process
- Circadian Regulation Of Gene Expression
- Enamel Mineralization
- Epidermis Development
- Fatty Acid Metabolic Process
- Fatty Acid Transport
- Heart Development
- Lipid Metabolic Process
- Lipoprotein Metabolic Process
- Negative Regulation Of Appetite
- Negative Regulation Of Blood Pressure
- Negative Regulation Of Cholesterol Storage
- Negative Regulation Of Glycolytic Process
- Negative Regulation Of Inflammatory Response
- Negative Regulation Of Leukocyte Cell-Cell Adhesion
- Negative Regulation Of Macrophage Derived Foam Cell Differentiation
- Negative Regulation Of Neuron Death
- Negative Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Receptor Biosynthetic Process
- Negative Regulation Of Sequestering Of Triglyceride
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Transcription Regulatory Region Dna Binding
- Positive Regulation Of Fatty Acid Beta-Oxidation
- Positive Regulation Of Fatty Acid Oxidation
- Positive Regulation Of Gluconeogenesis
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Circadian Rhythm
- Regulation Of Glycolytic Process By Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Lipid Transport By Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Response To Hypoxia
- Response To Insulin
- Transcription Initiation From Rna Polymerase Ii Promoter
- Wound Healing
Drug Interactions:
- Clofibrate
- Fenofibrate
- Indomethacin
- Bezafibrate
- Gemfibrozil
